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Pharm Res 16:13651368

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Nrf2, Nuclear factor erythroid 2 related factor 2

Oxidation of cysteine residues can result in a wide range of redox-based, post-translational modifications, including S-nitrosylation, S-glutathionylation and sulfinic acid, sulfenic acid and disulfide formation 22,23 , which can generate conformational changes in protein structure and subsequent modulation of protein activity 24

In terms of metabolism, ROS affect numerous metabolic processes such as glycolysis, lipid oxidation, amino acid utilization, and nucleotide synthesis, shaping the intricate metabolic landscape of cells [154, 156, 167, 546]

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