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Using gene editing tools such as CRISPR/Cas9, researchers can knock out key genes like PHGDH to directly regulate serine synthesis at the genetic level

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Catechin attenuates traumatic brain injury-induced blood-brain barrier damage and improves longer-term neurological outcomes in rats

55,56 Genetic or pharmacological inhibition of ACSL4 inhibited ferroptosis by preventing the esterification of AA or AdA into PE, which was the only lipid oxidized in endoplasmic-reticulum-associated compartments during ferroptosis
