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Disrupting this signaling circuit with the selective inhibitor SP600125 restores mitochondrial membrane potential, curtails keratinocyte hyper proliferation and cytokine release in vitro, and markedly mitigates epidermal hyperkeratosis and inflammation in an imiquimod induced psoriasis model, highlighting JNK inhibition as a promising strategy for redox driven skin pathology

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Its key enzymes and the entire pathway not only act as driving factors of tumor development, but also provide theoretical support and potential targets for targeted therapy and its combination with immunotherapy

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