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Variant calling was performed using the Genome Analysis Tool Kit (version 1.4) [26] followed by functional annotation using Annovar [27] and SnpEff [28]

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The picture is further muddied by limitations in the studies, and different study designs, e.g., variations in patient populations, dosages, treatment durations, and outcomes, which make it impossible to synthesize a final answer to whether L-carnitine works