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233 In one large observational study that followed nearly 500,000 participants for about 11 years, drinking up to 34 cups per day of any type of coffee, including decaffeinated, instant, or ground coffee, was associated with lower risks of all types of chronic liver disease, including NAFLD, as well as cirrhosis and hepatocellular cancer

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Conversely, in the peripheral variant, histamine discharge from mast cells triggers the activation of itch receptors at the epidermal-dermal interface

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