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FIGURE 3 7.1 Flavonoids: multitarget antioxidants and metabolic regulators Flavonoids exert hepatoprotective effects through synergistic mechanisms that include direct ROS scavenging, activation of antioxidant pathways, and metabolic regulation

Keywords: IGF-1 LR3, Long Arg IGF-1, Insulin-Like Growth Factor Analogue, Synthetic Growth Factor

In addition, IGF-1 possesses anti-atherogenic properties reflected in its role in modulating endothelial junction protein levels and promoting angiogenesis in endothelial cells (ECs) (23, 24)

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These observations support the neurogenic hypothesis of depression, which posits that impaired hippocampal neurogenesis contributes directly to mood dysregulation and treatment resistance ( Importantly, hippocampal neurogenesis is highly sensitive to inflammatory cytokines, oxidative stress, and mitochondrial dysfunction, further linking this mechanism to broader neuroimmune and metabolic abnormalities in depression