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Differential metabolites revealed three key insights into melasma therapy: First, the reduction of melanogenic precursors including benzoic acid strongly correlated with MASI score improvement, supporting their role in melanin regulation [2]

These effects may be due to vagus nerve stimulation of adrenal catecholamine production (Torres-Rosas et al., 2014), as patients with sepsis often show adrenal insufficiency (Marik and Zaloga, 2003)

DeLano FA, Schmid-Schnbein GW

Interestingly, however, both isoforms of IGF-1 were protective against age-related loss of muscle mass and force [65]