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Bajwa, H
Taken together, these results indicate that increased SLC7A11-driven CYS 2 uptake (via xCT) is the primary mechanism by which NRF2 activation increases the abundance of sugarCYS conjugates
Subsequent yeast studies helped further characterize this membrane-associated toxicity: wt human S expression in yeast (which lack an S gene) led to vesicle clustering/aggregation 67,68 and vesicle-trafficking defects
These data indicate that synaptic AMPARs are on average closer to SYT1 nanoclusters than are synaptic NMDARs
[DOI] [PMC free article] [PubMed] [Google Scholar] (385).Dueber JE
FERNANDEZ-MARCOS P J AUWERXJ
