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Two-needle electrodes for non-references (MLA1203 needle electrode, AD Instruments, Dunedin, New Zealand) were inserted into the middle portion of the lateral head at the bilateral gastrocnemius, respectively, to record bilateral responses from both gastrocnemius muscles simultaneously (Figure 2B)

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A possible explanation for this phenomenon is that these subjects are at maximum physiologic compensation with a high baseline oxidative burden

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Notably, several of the pro-inflammatory cytokines known to upregulate CD38 expression, including IL-6, interferons, TGF-, as well as SASP, are also implicated in SSc 2

Co-authored by Mike Garcia This article was co-authored by Mike Garcia