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Abbreviations ACTB: -Actin ACSL4: Acyl-CoA synthetase long-chain family member 4 AQP5: Aquaporin 5 CCK-8: Cell counting kit-8 CHIP: Chromatin immunoprecipitation DAB: Diaminobenzidine DEGs: Differentially expressed genes EGCG: Epigallocatechin-3-gallate ELISA: Enzyme-linked immunosorbent assay ER: Estrogen receptor-alpha FLS: Focal lymphocytic sialadenitis GO: Gene ontology GSH: Glutathione H&E: Hematoxylineosin ICR: Institute of Cancer Research IHC: Immunohistochemistry IFN: Interferon- IL: Interleukin JAK2: Janus kinase 2 KEGG: Kyoto Encyclopedia of Genes and Genomes MD: Molecular dynamics MDA: Malondialdehyde NOD: Nondiabetic obese OE RNA: RNA overexpression RMA: Robust multiarray mean algorithm RNA-FISH: RNA-fluorescence in situ hybridization RT-qPCR: Real-time quantitative polymerase chain reaction SGECs: Salivary gland epithelial cells shRNA: Short hairpin RNA siRNA: Short interfering RNA SPR: Surface plasmon resonance SS: Sjgrens syndrome SSB: Sjgrens syndrome antigen B (autoantigen La) STAT3: Signal transducer and activator of transcription 3 TEM: Transmission electron microscopy VEGF: Vascular endothelial growth factor XCI: X chromosome inactivation Xi: Inactivated X Xist : X-inactive specific transcript References Conrad N, Misra S, Verbakel JY, Verbeke G, Molenberghs G, Taylor PN, et al

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