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Additionally, a study involving rats indicated that decreased E2 levels could diminish cardiac vagal inhibition of renal sympathetic nerves while simultaneously enhancing cardiac sympathetic excitation, leading to a significant overall increase in reflex-driven sympathetic excitability (116)

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In addition, protein expression with ALS-associated mutations reduces LLPS and enhances aggregation 52

In the Phase III clinical trials, mRNA-1020 and 1030 have demonstrated the ability to generate robust immune responses to both COVID-19 and influenza antigens 41

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10.1016/j.amjmed.2019.03.050 96