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Cells were plated at approximately 3 10 4 cells per well in a 96-well plate (Eurofins DiscoverX) or 1 10 4 in a 384-well plate (in-house) and cultured for 1520 h at 37 C and 5% CO 2 prior to compound treatment

The influence of lead exposure on male semen parameters: A systematic review and meta-analysis

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FIGURE 4 Individual-centric spheroids identified subjects with dose-dependent and dose-independent toxicity at clinically relevant drug exposure Intrinsic DILI is generally not a major concern for the pharmaceutical industry because it is dose-dependent, predictable across populations, and its mechanisms are typically well understood