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Overall, the causal role of NAT2 in INH hepatotoxicity remains controversial and the detailed mechanism is still unknown 6

Liu, M., Ding, J., Peng, Y., Fang, J., Zhao, M., Zhang, W., et al

Recent findings highlight mitochondrial phosphorylated dynamic-related protein 1 (Drp1S616P) as a novel interorganellar tethering protein that localizes to the MLCS through interaction with Rab7, thereby enhancing crosstalk between these organelles (Che et al., 2022)

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Health benefits and anti-inflammatory activities have been attributed to the activity of tocochromanol catabolites, especially the 13'-COOH catabolite since it inhibits 5-lipoxygenase a key enzyme in the biosynthesis of leukotrienes from arachidonic acid

For severe deficiencies, especially those with neurological symptoms, a full resolution of symptoms might take several weeks or even months of consistent treatment