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In addition, melasma is more predominant in the female gender and it has been reported that females are 910 times more prone to melasma disorder in comparison to males (Majid and Aleem, 2021)

Hence, it is evident that periodontitis is a multifactorial disease, affiliates with specific microorganisms, social and behavioral factors, genetic or epigenetic trait, all of which are modulated and controlled by the underlying immune and inflammatory responses of the host [1]

Wilcox et al., 2011)

It also helps to protect the skin from damage by ultraviolet rays of the sun and prevents sunburns

Conversely, changes in the composition of intestinal fungal (called fungal dysbiosis) can lead to colon cancer, alcoholic liver disease, and allergic respiratory disease (Wheeler et al., 2016