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Antioxidant and anti-aging activities of polysaccharides from Calocybe indica var

AUC, Area under the plasma concentration-time curve

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This improved potency is likely due to the prodrug design of E-Met: the conjugation of a gamma-glutamyl moiety may alter the pharmacokinetic profile of Met by enhancing cellular uptake or reducing renal clearance ( To validate the GGT-dependency of E-Mets efficacy, we performed in vitro and in vivo GGT inhibition experiments using GGsTop