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For instance, pH-sensitive systems exploit the acidic milieu of inflamed or ischemic brain regions (pH 6.56.8) and endolysosomal compartments (pH 4.56.0) to trigger disassembly of polymeric micelles, liposomes, or dendrimer hybrids loaded with curcumin, resveratrol, or withanolides

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Much of this is thanks to theobromine, caffeine, and all those flavonols

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The surge of proinflammatory macrophages, and decay of adipocytes, leads us to speculate that NF-B/MAPK activation may come from macrophages rather than from adipocytes themselves

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