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Major metabolites found were trimethylamine N-oxide, primarily in urine (8% to 49% of the administered dose) and [ 3H]--butyrobetaine, primarily in feces (0.44% to 45% of the administered dose)

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[Link] Lau, T, et al, Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. in Molecular Psychiatry , Volume 22, Issue 2 February 2017, pp 227 - 234

It is hypothesized that CSD, which results in migraine, may be caused by increased neuronal excitability (Sparaco et al., 2006)

This ATP deficiency disturbs multiple ATP-dependent processes, such as electrolyte transport, substrate utilization, and contractile protein interactions, resulting in impaired myocardial contractility

Diabetes Care 34 , 22202224 (2011)