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Recently, desensitization of MOR expressed in the neurons from locus coeruleus was demonstrated to result from a decrease of both number of active receptors and the affinity of residual receptors for the agonist (Williams, 2014)
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

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Eur J Pharm Biopharm (2020) 153:27384

It is simpler and safer to reconstitute at your target concentration directly
