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Comparing Pernicious Anaemia to Other Causes of B12 Deficiency Pernicious Anaemia Caused by antibodies against intrinsic factor, a lack of intrinsic factor and/or autoimmune destruction of stomach cells that produce intrinsic factor

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The metabolomics data can confirm the role of oxidative stress and metabolic alterations in cellular processes, including redox homeostasis, energy balance, membrane integrity, and lipid metabolism by DON (Figure 1) (115)