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doi:10.1073/pnas.0230450100 Gaylor J (2002) Membrane-bound enzymes of cholesterol synthesis from lanosterol

Upon receptor engagement in research models, IGF-1 LR3 activates two major downstream signaling cascades: - PI3K/Akt/mTOR pathway associated with cellular survival, protein synthesis, and anabolic signaling processes in experimental models

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Experiments on shRNA infected cells were performed 45 days post-transduction

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