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1996 Oct 25;52(8):1147-54

Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

H.SchrankA.et al (2008)

A strong association of insulin resistance has also been shown in patients with unexplained fertility problems, presuming that elevated blood insulin levels may impair spermatogenesis, and in patients with hyperinsulinemia and type 2 diabetes, also generate nuclear and mitochondrial DNA damage in sperm (178, 188)

[DOI] [PubMed] [Google Scholar] 348.Li Y., Ruan R., Chen P.L., Liu Z., Pan X., Lin X., Liu Y., Mok C., Yang T

Further mechanistic studies reveal that AT-III activates AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), subsequently increasing PGC-1 expression and promoting its deacetylation (Han et al., 2022)