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Proper reconstitution technique requires injecting bacteriostatic water slowly down the vial wall, allowing passive dissolution for 510 minutes, and never shaking the solution

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Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features

Altogether, these results demonstrate that APR-246 induces GSH depletion which induces ferroptosis in AML cells irrespective of their TP53 mutational status, and that ferroptosis induction is the main mechanism of cell death after early exposure to APR-246