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Oxidized, heme-depleted Hb forms precipitates (Heinz bodies), which accumulate within the cells, resulting in membrane rigidity and decreased RBC deformability (151)

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Makris S.L., Kim J.H., Ellis A., Faber W., Harrouk W., Lewis J.M., Paule M.G., Seed J., Tassinari M., Tyl R

Gadhave DG, Sugandhi VV, Jha SK, Nangare SN, Gupta G, Singh SK, Dua K, Cho H, Hansbro PM, Paudel KR

Various factors, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death, have been shown to induce renal tubular injury and contribute to the progression of DKD

compared autologous PRP to platelet-poor plasma (PPP) and found that wound healing was achieved in nine out of ten patients in the PRP group, but in none of the patients in the PPP group by day 84 [51]

Cell 167:313324 Acknowledgements This research was funded by the National Key R&D Program (Grant No
