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GHK-Cu is effective topically Metal involvement : GHK-Cu specifically involves copper delivery

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Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA

This metal-binding arrangement influences the physicochemical properties of the complex and has made GHK-Cu a widely studied model system for investigating copper coordination chemistry, ligand-metal interactions, metallopeptide stability, and copper-dependent signaling mechanisms

Collectively these processes may ultimately lead to the death of neurons