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The Phase 2 clinical trial showed roughly 2-3 kg more fat loss than placebo over 12 weeks, with no impact on blood sugar, insulin, IGF-1, or any hormonal marker

The STEP trials reported nausea in approximately 44% of participants on semaglutide 2.4 mg versus 17.4% on placebo

it also found increasing memory impairment as B12 levels dropped even whilst within currently defined acceptable ranges and that B12 interventions are effective once levels are less than 300 pmol/L

Set realistic expectations

It is converted to coenzyme B12 in the body and in this form facilitates the conversion of homocysteine to methionine (methylcobalamin) and plays an important role in converting methylmalonyl-coenzyme A to succinyl-Co-A (fatty acid and amino acid metabolism)

Adding 2mL gives 5mg/mL (20 units = 1mg)