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In patients who already produce normal or elevated levels of endogenous GLP-1, flooding those same receptors with long-acting agonists may push a finely tuned system past its adaptive range

[DOI] [PubMed] [Google Scholar] 51.Piccoli GF, Mesquita LA, Stein C, Aziz M, Zoldan M, Degobi NAH, et al

A GLP-1 diet is a smart way of eating that works well with this group of medicines (GLP-1 agonists)

2024;143 doi: 10.1016/j.intimp.2024.113537

Several factors contribute to the increased risk of colon cancer in individuals with obesity, including alterations in systemic growth factors, visceral adipose tissue, the microbiome, bile acids, inflammation, and a diet rich in fat, sugar, high fructose corn syrup, or low vitamin D

Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease