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The proposal and subsequent validation of this concept fundamentally reshaped the understanding of T-cell repertoire composition in tumors, prompting a fundamental reassessment of the mechanisms underlying T-cell-mediated immunosurveillance and the precise targets of tumor immunotherapy

Lee and colleagues demonstrated that MOTS-C administration prevents diet-induced obesity and insulin resistance in mouse models (Lee et al., Cell Metabolism 2015

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1 Poor prognostic signs include multi-organ failure, which may involve cerebral edema, renal failure, profound hypoglycemia and lactic acidosis, any signs of which should prompt an immediate liver transplant evaluation