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The SURPASS program (for type 2 diabetes) and SURMOUNT program (for obesity) together enrolled over 20,000 participants across multiple Phase III trials
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The progressive loss of nephrons reduces renal 1-hydroxylase activity, limiting the production of active 1,25-dihydroxyvitamin D (1,25(OH)D), whereas urinary loss of vitamin D-binding protein (VDBP) due to proteinuria further exacerbates 25(OH)D deficiency (3)
LaGrant, B., Marquis, B
