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Onset of Appetite Suppression The time it takes for tirzepatide to suppress appetite varies among individuals: Within Hours: Some individuals may experience appetite suppression within hours (some individuals on Reddit report 12 24 hours with 2.5mg) due to heightened sensitivity to incretin hormones or variations in central nervous system receptors

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The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication

This is why many people experience peak side effects in weeks one and two at a new dose, with gradual improvement in weeks three and four

Staged initiation : Consider starting tirzepatide first, allowing 8-12 weeks for dose titration and gastrointestinal adaptation before adding creatine supplementation