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Excess intracellular iron results in formation and deposition of hemosiderin which can lead to cellular dysfunction and damage

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The 1,25(OH)D+Erastin group consisted of NPCs that underwent pre-treatment with 10 nmol/L 1,25(OH)D for 48 h, followed by a 24 h treatment with 10 mol/L Erastin

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EMBO J 21:22632271 Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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