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10.1038/s41575-020-00381-6 33 KeY.LiD.ZhaoM.LiuC.LiuJ.ZengA.et al (2018)

While researchers are making strides in understanding the exact structure of the carnitine transporter protein, these discoveries have not yet led to clinical gene therapy or gene-editing trials [5]

These examples show some common manifestations

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A recent meta-analysis revealed significant improvements in fasting blood glucose, insulin resistance, triglycerides (TG), total cholesterol, LDL cholesterol, weight, and BMI [212]

Among them, various signaling pathways as drug targets have been investigated, such as TNF, PDGF, JAK-STAT, PGE2, PDGF, NADPH oxidase, integrin inhibition, mTOR inhibition, and so on