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Nevertheless, despite substantial progress in understanding the impacts of microplastics and nanoplastics on organ and system functioning, several critical gaps remain, including the need for timely detection and objective assessment of their toxicity and contribution to disease development, as well as the investigation of potential hidden and long-term effects, including possible influences on genetic mechanisms

In addition, the oldest orphan nuclear receptor estrogen-related receptor (ERR), an important regulator of metabolic gene transcription and innate immune function, including those induced by toll-like receptor (TLR) and antimicrobial activities against intracellular bacterial infection [147], facilitated post-translational activation of autophagy by deacetylating various autophagy-related proteins, including ATG5, BECN1, and ATG7

[PubMed 2389789] 1364

It acts primarily through gene expression modulation, delivering copper to enzymes and triggering transcription factor cascades rather than saturating one receptor

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