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Overall, more studies are needed to further clarify the precise role of these time-dependent events in AILI, thus making the late phase therapy become possible in clinical

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CD8 + T cells treated with ML226 appeared to be able to rewire 2-OG metabolism, without major effects on 2-OGDD activity

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Alkali injury-induced pathological lymphangiogenesis in the iris facilitates the infiltration of T cells and ocular inflammation

However, IR3 can sometimes act as an IGF1 mimetic and especially in cells overexpressing the IGF-1R (Kato et al, 1993)