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In the pivotal 2018 animal study by Neelakantan et al., systemic treat Mechanism of Action 5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH) as products

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Am J Ophthalmol 2005

Internal proteins such as the polymerase subunits (PA, PB1, PB2), matrix and nucleoprotein can have conservation in sequence of 7797% within influenza A but much reduced conservation with influenza B species
