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Additionally, CoQ10 binds to the mitochondrial permeability transition pore, preventing mitochondrial depolarization and cytochrome C release to lower cysteine protease-3 activation and reduce apoptosis (Hseu et al., 2018

doi: 10.1016/j.tips.2007.02.003 217 ZhangQZhuBLiY

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Also, hypothalamic-pituitary-adrenal insufficiency in patients with CFS has been described as a result of activation of the immune and inflammatory pathways [4]