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Early clinical trial data from the Phase 2 studies published in the New England Journal of Medicine suggest that retatrutide may indeed have a favourable profile when it comes to body composition

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Researchers should note that most indirect comparisons carry the limitations inherent to cross-trial analyses, including differences in baseline populations and trial design

This observation also highlights the complexity that modifying a residue within a cholesterol binding site might have on the overall pattern of receptor interactions with cholesterol and other plasma membrane lipids, as increased segregation to cholesterol-rich lipid rafts occurs despite an overall reduction in total cholesterol binding under vehicle conditions observed for the V229A mutant receptor