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PMID: 30 Carrillo-VicoALardonePJNajiLFernndez-SantosJMMartn-LacaveIGuerreroJMet al

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Perlmutter DH Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking

Pharmacological blockade or genetic silencing of CTSD effectively attenuates high glucoseinduced cell death, confirming its pathogenic role (Yamashima et al., 2022)

However, what many believe to be the key factor are the sulfur groups in glutathione, which represent the very core of its protective role
