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Conclusion Fatigue poses a substantial challenge for people with MS, affecting a large majority, with more than 50% of patients considering it their most disabling symptom
This phosphorylation of eIF2 subsequently causes increased transcription of stress genes, notably ATF4, resulting in elevated FGF21 expression
Persistent fatigue may indicate inadequate B-vitamin cofactor status
[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Rastrelli G, Corona G, Maggi M
