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In therapy, Panobinostat induces CD38 upregulation, thereby improving the anti-myeloma effects of Daratumumab ( 2.1.1.3 JAK-STAT signaling pathway The JAK-STAT pathway can influence CD38 regulation through its signaling activities

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Neurological applications include diabetic neuropathy, multiple sclerosis symptom management, and Bell's palsy recovery

Thus, through high consumption of NAD + , CD38 also indirectly impacts the activity of other NAD + -consuming enzymes such as sirtuins 52