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doi: 10.1056/NEJMoa011110 97 WallisRSBroderMSWongJYHansonMEBeenhouwerDO

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Control patients (n = 28) received standard of care treatment only, while NAC patients (n = 28) received the standard of care treatment plus N-acetyl cysteine

This enhancement is attributed to acetylation-induced alterations in the binding properties of NRF2 with transcription factors, increasing the affinity of NRF2 for DNA binding, and consequently driving the expression of relevant genes

Furthermore, insulin resistance can lead to abnormal lipid profiles, like low-HDL and high triglyceride (TG) levels