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There is evidence that the full inhibition of Complex I that prevents increased ROS generation impairs hypoxic adaptation in tumor cells by rewiring mitochondrial metabolism, and the antitumorigenic effect of ROS signaling is lost [39]

The gastrointestinal tract constitutes a dynamic interface mediating host-environment interactions and functions as an essential barrier that is pivotal in maintaining immune homeostasis 69

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Overall, aligning immunotherapy with circadian rhythms offers a novel strategy to enhance anti-tumor immunity, and ongoing research is critical to validate and refine this approach, potentially leading to more effective and personalized cancer treatments [110]

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