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Bedrosian recommend a more cautious approach

Pregnancy and Breastfeeding Topical use is considered low-risk, but definitive clinical safety data are limited

145,146 In one controlled trial, 198 airline passengers with moderate to high risk of venous thrombosis were given either pycnogenol, at 200 mg before and during a long flight (averaging 8 hours 15 minutes) plus 100 mg the next day, or placebo

The MOTS-c benefits guide covers the metabolic mechanisms, and the MOTS-c dosage chart provides protocol specifics

And nobody explains why their protocol is the right one

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