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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

Those with more adipose tissue or slower initial response may benefit from increasing to 400-500mcg

NOAEL=no-observed-adverse-effect level

Once reconstituted, refrigeration is recommended, with long-term storage at 20 C

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Collectively, these findings support the interactions of GHK and GHK-Cu complexes with mammalian models as research tools for studying redox regulation, peptide-mediated antioxidant signaling, and oxidative stress modulation