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As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

Studies involving intravenous AOD-9604 use in humans report a half-life of 3min

Megaloblastic anemia of the pernicious variety is brought on by a deficiency in the intrinsic factor, which prevents the absorption of vitamin B12

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H.) and the Department of Medicinal Chemistry and Molecular Pharmacology (R