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Consistent with these findings, in vivo experiments revealed a significant reduction in Sirt1 protein expression in the livers of mice upon NNMT knockdown

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Relative to young adults, GSH levels in peripheral blood were decreased in old adults in the majority (6/9, 67% including age-overlap studies) of studies, indicating an increase in OS with age (Bajic et al., 2019, Zhu et al., 2006)

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