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In addition, the researchers observed low levels of selenium, zinc, magnesium, chromium, and malondialdehyde and high rates of oxidative stress marker 8-isoprostaglandin F2 alpha in the blood of the patients, when compared to the controls (Muhammad et al

The authors point out that these effects may be mediated by the c-Fos/IL-10/stat3 signaling pathway ( Multiple neurodegenerative diseases accompanied by ischemic phenomena are associated with a decrease in KGDHC activity and accumulation of KG, which may contribute to the implementation of KG multifunctionality ( 4

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