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It has a critical role in protecting cells from oxidative stress and maintaining the immune system

Front Hum Neurosci 15:648816 Hermens DF, Hatton SN, Lee RSC et al (2018) In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders

D.MiyashiroK.et al

5 Gut microbiota and metabolites targeted interventions against CKD progression in the gut-brain-kidney axis Gut dysbiosis is implicated in the progression of a range of diseases, including cardiovascular disease, type 2 diabetes, neurodegenerative conditions, and CKD, among others, via mechanisms that are yet to be completely understood

In addition, membrane contact sites, such as ERmitochondria and ERlysosome interfaces, are being actively investigated as potential conduits for lipid peroxidation signals 90,91

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