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CD8 + T cells exhibit higher infiltration levels in metastatic brain lesions than in primary brain tumors, such as gliomas [66], but most of these cells are in a functionally exhausted state, with increased expression of inhibitory receptors such as PD1 and TIM3 [67]
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Mocholi E, Russo L, Gopal K, Ramstead AG, Hochrein SM, Vos HR, et al
