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Meanwhile, GTP cyclohydrolase 1/tetrahydrobiopterin counteracts ferroptosis through lipid remodeling (41), but blockade of DHFR synergizes with GPX4 inhibition to induce ferroptosis (42)

10.1111/j.1399-3054.1996.tb00497.x 19 BrizardJ

Most characterized selenoproteins are oxidoreductases and catalyze important redox reactions, such as the degradation of peroxides (glutathione peroxidase or GPx isoforms) and the reduction of thioredoxin (thioredoxin reductase or TrxR isoforms)

10.1016/j.bcp.2017.02.009 [DOI] [PubMed] [Google Scholar] 67.Rehm SRT, Smirnova NF, Morrone C, et al

Antioxidants in turmeric may alsoreduce therisk ofcataracts, glaucoma and macular degeneration