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Sparc-related modular calcium-binding protein 1 (SMOC1) has been identified as a glucose-responsive hepatokine that modulates dynamic glucose homeostasis by enhancing glycaemic control and insulin sensitivity independently of insulin secretion [197]

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Among these, high-penetrance monogenic forms of PD mainly include SNCA, VPS35, PRKN/PARK7/PINK1, while genes with variable penetrance primarily include LRRK2 and GBA [16]

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